DELETION OF A PATHOGENIC MUTATION-CONTAINING EXON OF COL7A1 ALLOWS CLONAL GENE EDITING CORRECTION OF RDEB PATIENT EPIDERMAL STEM CELLS

Deletion of a Pathogenic Mutation-Containing Exon of COL7A1 Allows Clonal Gene Editing Correction of RDEB Patient Epidermal Stem Cells

Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by loss of functional type Chair Band VII collagen at the dermal-epidermal junction.A frameshift mutation in exon 80 of COL7A1 gene, c.6527insC, is highly prevalent in the Spanish patient population.We have implemented gene-editing strategies for COL7A1 frame resto

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Quality and resource efficiency in hospital service provision: A geoadditive stochastic frontier analysis of stroke quality of care in Germany.

We specify a Bayesian, geoadditive Stochastic Frontier Analysis (SFA) model to assess hospital performance along the dimensions of resources and quality of stroke care in German hospitals.With 1,100 annual observations Chair Band and data from 2006 to 2013 and risk-adjusted patient volume as output, we introduce a production function that captures

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Realistic Human Exposure at 3.5 GHz and 28 GHz for Distributed and Collocated MaMIMO in Indoor Environments Using Hybrid Ray-Tracing and FDTD

Realistic human downlink exposure at 3.5 and 28 GHz to Air Acetylene Outfit electromagnetic fields is evaluated for distributed and collocated base stations using a hybrid ray-tracing/finite-difference time-domain method.For the first time, the absorbed power density is computed for distributed massive multiple-input multiple-output (DMaMIMO) 6G ba

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Multifunctional corporation as an extremely complicated nonlinear system, the problem of its mathematical modeling and its solution using cognitive technologies

Multiindustry corporations represent the amalgamation of a large number of business entities of various legal forms (legal entities and individuals) in order to more effectively conduct a common business.At the same time, economic entities that are parts of the corporation retain their independence, but coordinate their activities with one another

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